What’s happening
2025
Dr. Monroe was awarded a one-year (2025-2026) fellowship from the NHLBI Cardiovascular Development Data Resource Center! With this support, he aims to develop a quantitative tool that integrates both common and rare genetic variation to improve congenital heart disease (CHD) risk assessment. Using this tool, he also aims to better understand how genetic variation beyond primary pathogenic variants might influence carrier penetrance and expressivity.
Commentary on genetic burden in telomere biology disorders
Dr. Monroe’s commentary on cumulative genetic liability in telomere biology disorders was published in JCI. The work referenced has broader implications for heritable complex traits where common and rare variants interact to scale risk. (Read the commentary in JCI; Referenced study by Poeschla et al.)
2024
American Heart Association service
Dr. Monroe was invited to serve as Fellow in Training on the AHA BCVS Leadership Committee of the Council on Basic Cardiovascular Sciences until July 2026. He is thrilled to be selected to help shape the future of the BCVS!
2023
NHLBI K99 is active! Great news. The NHLBI selected Dr. Monroe’s K99, “Mechanisms linking the frail sarcomere to noncompaction cardiomyopathy” for funding. This award will help us use engineered tissues to understand how myosin heavy chain variants influence cardiomyocyte maturation - linking developmental pathways to sarcomere integrity.